Dampak Anemi Defisiensi Besi pada Kehamilan : a Literature Review

Lilik Hidayanti, M.Zen Rahfiludin

Sari

Ibu hamil yang menderita anemia defisiensi besi dapat memberikan dampak negative pada kesehatan ibu maupun bayi yang dilahirkan sehingga dapat meningkatkan angka kematian ibu (AKI) dan angka kematian anak (AKB). Literature review ini bertujuan untuk melakukan telaah terhadap artikel-artikel hasil penelitian eksplanatori dan eksperimental yang dipublikasikan 10 tahun yang lalu atau mulai dari tahun 2008 terkait dengan dampak anemia defisiensi besi pada ibu saat hamil dengan outcome kehamilannya seperti prematuritas, BBLR, kejadian preeklamsi, perkembangan kognitif anak dan kematian bayi. Hasil penelusuran melalui 4 electronic search engine yaitu Proquest, CINAHL Medline, dan Scopus menemukan 220 artikel. Setelah dilakukan proses skrining berdasarkan kriteria inklusi yang ditetapkan, maka diperoleh 50 artikel yang akan ditelaah. Hasil telaah artikel yang telah kami lakukan menemukan bahwa paling banyak (21) artikel membahas mengenai dampak anemia defisiensi besi pada ibu hamil dengan kejadian BBLR, 18 artikel dengan kejadian prematuritas, 6 artikel dengan perkembangan mental anak, dan sisanya (5) artikel dengan kadar zat besi dalam tubuh bayi baru lahir dan ourcome kehamilan yang lainnya. Hasil penelitian di berbagai Negara baik Negara berkembang maupun Negara maju menunjukan bahwa anemia yang terjadi pada masa kehamilan dapat memberikan dampak kelahiran dengan BBLR, prematuritas, kematian neonatus, anemia neonatus, kelahiran denga  metode sectio, hambatan perkembangan mental, dan rendahnya skor APGAR.

Kata Kunci

Anemia defisiensi besi; wanita hamil; dampak kehamilan

Teks Lengkap:

PDF

Referensi

Abioye, A. I. et al. (2018) ‘Anemia of inflammation during human pregnancy does not affect newborn iron endowment’, Journal of Nutrition, 148(3), pp. 427–436. doi: 10.1093/jn/nxx052.

Abir, T. et al. (2017) ‘The impact of antenatal care, iron–folic acid supplementation and tetanus toxoid vaccination during pregnancy on child mortality in Bangladesh’, PLoS ONE, 12(11), pp. 1–15. doi: 10.1371/journal.pone.0187090.

Ahankari, A. S. et al. (2017) ‘Risk factors for maternal anaemia and low birth weight in pregnant women living in rural India: a prospective cohort study’, Public Health. Elsevier Ltd, 151, pp. 63–73. doi: 10.1016/j.puhe.2017.06.023.

Al-Mamouri, R. H. L. and Al-Hakeem, A. H. (2018) ‘The impact of Iron deficiency anemia on histomorphological features of placenta and the new born infants’, Journal of Global Pharma Technology, 10(3), pp. 1045–1048.

Ali, A. A. et al. (2011) ‘Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan’, BMC Research Notes. BioMed Central Ltd, 4(1), p. 311. doi: 10.1186/1756-0500-4-311.

Alwan, N. A. et al. (2015) ‘Maternal iron status in early pregnancy and birth outcomes: insights from the Baby’s Vascular health and Iron in Pregnancy study’, British Journal of Nutrition, 113(12), pp. 1985–1992. doi: 10.1017/s0007114515001166.

Bakacak, M. et al. (2015) ‘The effect of maternal hemoglobin concentration on fetal birth weight according to trimesters’, Journal of Maternal-Fetal and Neonatal Medicine, 28(17), pp. 2106–2110. doi: 10.3109/14767058.2014.979149.

Beard, J. (2003) ‘Neurocognitive Function and Trace Elements’, J. Nutr, 133(April), pp. 1468–1472.

Berglund, S. K. et al. (2017) ‘The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring’, British Journal of Nutrition, 118(7), pp. 533–540. doi: 10.1017/S0007114517002410.

Bhutta, Z. A. et al. (2017) ‘Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence’, Pediatrics, 115(Supplement 2), pp. 519–617. doi: 10.1542/peds.2004-1441.

Brannon, P. M. and Taylor, C. L. (2017) ‘Iron Supplementation during Pregnancy and Infancy : Uncertainties and Implications for Research and Policy’, pp. 1–17. doi: 10.3390/nu9121327.

Drukker, L. et al. (2015) ‘Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes’, Transfusion, 55(12), pp. 2799–2806. doi: 10.1111/trf.13252.

Elhassan E, Abbaker A, Haggaz A, Abubaker M, A. I. (2010) ‘Anaemia and low birth weight in Medani, Hospital Sudan. BMC Research Notes 3: 181. doi: 10.1186/1756-0500-3-181 PMID: 20584294’, pp. 0–4.

Fowkes, F. J. I. et al. (2018) ‘Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study’, BMC Medicine, 16(1), pp. 1–11. doi: 10.1186/s12916-018-1146-z.

Gaillard, R. et al. (2014) ‘Risk factors and consequences of maternal anaemia and elevated haemoglobin levels during pregnancy: A population-based prospective cohort study’, Paediatric and Perinatal Epidemiology, 28(3), pp. 213–226. doi: 10.1111/ppe.12112.

Gambling, L. et al. (2003) ‘Metal-Binding Proteins and Trace Element Metabolism Iron and Copper Interactions in Development and the’, Society, pp. 1554–1556.

Heydarpour, F. et al. (2019) ‘Maternal Anemia in Various Trimesters and Related Pregnancy Outcomes: Results from a Large Cohort Study in Iran’, Iranian Journal of Pediatrics, In Press(In Press). doi: 10.5812/ijp.69741.

Hibbeln, J. R. et al. (2017) ‘Meat Consumption During Pregnancy and Substance Misuse Among Adolescent Offspring: Stratification of TCN2 Genetic Variants’, 37(4), pp. 784–790. doi: 10.1183/09031936.00063810.The.

Huang, L. et al. (2015) ‘The Influence of Iron-deficiency Anemia during the Pregnancy on Preterm Birth and Birth Weight in South China’, Journal of Food and Nutrition Research, 3(9), pp. 570–574. doi: 10.12691/jfnr-3-9-2.

Indonesia, K. K. R. (2018) ‘Hasil utama Riskesdas 2018’, Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Kementrian Kesehatan Republik Indonesia.

Jwa, S. C. et al. (2015) ‘Changes in maternal hemoglobin during pregnancy and birth outcomes’, BMC Pregnancy and Childbirth, 15(1), pp. 1–10. doi: 10.1186/s12884-015-0516-1.

Kaur, M. (2015) ‘Maternal Anaemia and Neonatal Outcome: A Prospective Study on Urban Pregnant Women’, Journal of Clinical and Diagnostic Research, pp. 4–8. doi: 10.7860/JCDR/2015/14924.6985.

Koura, G. K. et al. (2012) ‘Anaemia during pregnancy: Impact on birth outcome and infant haemoglobin level during the first 18months of life’, Tropical Medicine and International Health, 17(3), pp. 283–291. doi: 10.1111/j.1365-3156.2011.02932.x.

Lawani, L. O. et al. (2016) ‘Obstetric benefits of health insurance : A comparative analysis of obstetric indices and outcome of enrollees and non-enrollees in southeast Nigeria’, 3615(May). doi: 10.1080/01443615.2016.1174830.

Lee, K. A., Zaffke, M. E. and Baratte-Beebe, K. (2002) ‘Restless Legs Syndrome and Sleep Disturbance during Pregnancy: The Role of Folate and Iron’, Journal of Women’s Health & Gender-Based Medicine, 10(4), pp. 335–341. doi: 10.1089/152460901750269652.

Lelic, M. et al. (2014) ‘Influence of Maternal Anemia During Pregnancy on Placenta and Newborns’, Medical Archives, 68(3), p. 184. doi: 10.5455/medarh.2014.68.184-187.

Levy, A. et al. (2005) ‘Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery’, European Journal of Obstetrics Gynecology and Reproductive Biology, 122(2), pp. 182–186. doi: 10.1016/j.ejogrb.2005.02.015.

Lumbanraja, S. N. et al. (2019) ‘The Correlation between Hemoglobin Concentration during Pregnancy with the Maternal and Neonatal Outcome’, Open Access Macedonian Journal of Medical Sciences, 7(4), pp. 593–597. doi: 10.3889/oamjms.2019.150.

Maka, S. S., Tondare, S. B. and Tondare, M. B. (2017) ‘Study of impact of anemia on pregnancy’, International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 6(11), p. 4847. doi: 10.18203/2320-1770.ijrcog20174692.

Masukume, G. et al. (2015) ‘Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort’, PLoS ONE, 10(4), pp. 1–15. doi: 10.1371/journal.pone.0122729.

McCarthy, E. K. et al. (2017) ‘Impact of maternal, antenatal and birth-associated factors on iron stores at birth: Data from a prospective maternal-infant birth cohort’, European Journal of Clinical Nutrition. Nature Publishing Group, 71(6), pp. 782–787. doi: 10.1038/ejcn.2016.255.

McCarthy, P. J. et al. (2016) ‘Impact of growth restriction and other prenatal risk factors on cord blood iron status in prematurity’, Journal of Pediatric Hematology/Oncology, 38(3), pp. 210–215. doi: 10.1097/MPH.0000000000000536.

Milman, N. (2012) ‘Postpartum anemia II: Prevention and treatment’, Annals of Hematology, 91(2), pp. 143–154. doi: 10.1007/s00277-011-1381-2.

Mir, M. K. et al. (2016) ‘Maternal anemia is a risk factor for low birth weight babies at term’, Pakistan Journal of Medical and Health Sciences, 10(3), pp. 741–743.

Mireku, M. O. et al. (2016) ‘Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function’, Pediatrics, 138(6), pp. e20161319–e20161319. doi: 10.1542/peds.2016-1319.

Misra, A., Ray, S. and Patrikar, S. (2015) ‘A longitudinal study to determine association of various maternal factors with neonatal birth weight at a tertiary care hospital.’, Medical journal, Armed Forces India, 71(3), pp. 270–3. doi: 10.1016/j.mjafi.2015.03.001.

Moos, T., Skjørringe, T. and Thomsen, L. L. (2018) ‘Iron deficiency and iron treatment in the fetal developing brain - A pilot study introducing an experimental rat model’, Reproductive Health, 15(Suppl 1). doi: 10.1186/s12978-018-0537-0.

Moradi, G. et al. (2017) ‘The Relationship between Maternal Diseases during Pregnancy and Low Birth Weight: a Nested Case-Control Study in Rural Areas of Kurdistan Province (West of Iran)’, MSc. Student in Epidemiology, 5(44), pp. 5501–5514. doi: 10.22038/ijp.2017.22666.1894.

Mosha, D. et al. (2016) ‘Dietary iron and calcium intakes during pregnancy are associated with lower risk of prematurity , stillbirth and neonatal mortality among women in Tanzania’, 20(4), pp. 678–686. doi: 10.1017/S1368980016002809.

Murray-Kolb, L. E. (2013) ‘Iron and brain functions’, Current Opinion in Clinical Nutrition and Metabolic Care, 16(6), pp. 703–707. doi: 10.1097/MCO.0b013e3283653ef8.

Nguyen, P. H. et al. (2016) ‘Impact of Preconception Micronutrient Supplementation on Anemia and Iron Status during Pregnancy and Postpartum : A Randomized Controlled Trial in Rural Vietnam’, pp. 1–17. doi: 10.1371/journal.pone.0167416.

Nisar, Y. Bin and Dibley, M. J. (2014) ‘Earlier initiation and use of a greater number of iron-folic acid supplements during pregnancy prevents early neonatal deaths in Nepal and Pakistan’, PLoS ONE, 9(11). doi: 10.1371/journal.pone.0112446.

Noronha, J. A. et al. (2012) ‘’, Journal of South Asian Federation Of Obstetrics and Gynaecology, 4(1), pp. 64–70. doi: 10.5005/jp-journals-10006-1177.

Perveen, S. and Soomro, T. K. (2016) ‘Sideropaenic anaemia: Impact on perinatal outcome at tertiary care hospital’, Journal of the Pakistan Medical Association, 66(8), pp. 952–956.

Petrou, S. (2003) ‘Economic consequences of preterm birth and low birthweight’, 110(April). doi: 10.1016/S1470-0328(03)00013-2.

Pinho-Pompeu, M. et al. (2017) ‘Anemia in pregnant adolescents: impact of treatment on perinatal outcomes’, Journal of Maternal-Fetal and Neonatal Medicine, 30(10), pp. 1158–1162. doi: 10.1080/14767058.2016.1205032.

Renz, P. B., Hernandez, M. K. and Camargo, J. L. (2018) ‘Effect of iron supplementation on HbA1c levels in pregnant women with and without anaemia’, Clinica Chimica Acta. Elsevier, 478(October 2017), pp. 57–61. doi: 10.1016/j.cca.2017.12.028.

RISKESDAS (2013) ‘Penyakit yang ditularkan melalui udara’, Jakarta: Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan Republik Indonesia, (Penyakit Menular), p. 103. doi: 10.1007/s13398-014-0173-7.2.

De Sá, S. A. et al. (2015) ‘Anemia in pregnancy: Impact on weight and in the development of anemia in newborn’, Nutricion Hospitalaria, 32(5), pp. 2071–2079. doi: 10.3305/nh.2015.32.5.9186.

Scholl, T. O. and Johnson, W. G. (2000) ‘Folic acid: influence on the outcome of pregnancy - Google Scholar’, 71. Available at: https://scholar-google-co-il.ezlibrary.technion.ac.il/scholar?q=Folic+acid%3A+influence+on+the+outcome+of+pregnancy&btnG=&hl=iw&as_sdt=0%2C5.

Shah-Kulkarni, S. et al. (2016) ‘Neurodevelopment in early childhood affected by prenatal lead exposure and iron intake’, Medicine (United States), 95(4), pp. 1–9. doi: 10.1097/MD.0000000000002508.

Singal et al. (1992) ‘Maternal outcome in pregnant women with anaemia’, 17(03). doi: 10.19571/j.cnki.1000-2995.2013.12.016.

Stangret, A. et al. (2017) ‘Maternal hemoglobin concentration and hematocrit values may affect fetus development by influencing placental angiogenesis’, Journal of Maternal-Fetal and Neonatal Medicine, 30(2), pp. 199–204. doi: 10.3109/14767058.2016.1168395.

Taljaard, C. et al. (2013) ‘Effects of a multi-micronutrient-fortified beverage , with and without sugar , on growth and cognition in South African schoolchildren : a randomised , double-blind , controlled intervention’, pp. 2271–2284. doi: 10.1017/S000711451300189X.

Tran, T. D. et al. (2014) ‘Infant motor development in rural Vietnam and intrauterine exposures to anaemia, iron deficiency and common mental disorders: A prospective community-based study’, BMC Pregnancy and Childbirth, 14(1), p. no pagination. Available at: http://www.biomedcentral.com/1471-2393/14/8%0Ahttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed16&NEWS=N&AN=52961885.

Wang, J. et al. (2015) ‘The Influence of Malnutrition and Micronutrient Status on Anemic Risk in Children under 3 Years Old in Poor Areas in’, pp. 1–14. doi: 10.1371/journal.pone.0140840.

Wanyama, R. et al. (2016) ‘Effect of maternal Helicobacter Pylori infection on birth weight in an urban community in Uganda’, BMC Pregnancy and Childbirth. BMC Pregnancy and Childbirth, 16(1), pp. 1–9. doi: 10.1186/s12884-016-0950-8.

World Health Organization (2001) ‘Iron Deficiency Anaemia: Assessment, Prevention and Control, A guide for program managers’, Who Guideline, pp. 1–114. doi: 10.1136/pgmj.2009.089987.

Yildiz, Y. et al. (2014) ‘The relationship between third trimester maternal hemoglobin and birth weight/length; Results from the tertiary center in Turkey’, Journal of Maternal-Fetal and Neonatal Medicine, 27(7), pp. 729–732. doi: 10.3109/14767058.2013.837445.

Refbacks

  • Saat ini tidak ada refbacks.